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KMID : 0378019890320030082
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New Medical Journal
1989 Volume.32 No. 3 p.82 ~ p.90
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Clinical Effects of Bromperidol and Haloperidol in Chronic Schizophrenia
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Abstract
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The purpose of this study was to compare the clinical effects of bromperidol to that of haloperidol. Fourty-nine DSM-III diagnosed chronic schizophrenic patients were orally administered bromperidol or haloperidol after wash out period. The dosage of bromperidol was 25.00 ± 4.47 mg / day, and that of haloperidol was 24.58±9.12 mg / day and the treatment period was 4 weeks. The clinical effects and extrapyramidal symptoms were evaluated by employing Brief Psychiatric Rating Scale and Extrapyramidal Rating Scale of Chouinard, respectively.
In general, patients reacted equally on both drugs. From the 14th day both groups showed
statistical significance in BPRS. In evaluating the scores of the BPRS items, bromperidod scored better than haloperidol in tension, mannerism and posturing, suspiciousness, hallucina
tory behavior, motor retardation and unusual thought content, while haloperidol scored better than bromperidol in anxiety, uncooperativeness and excitement.
The incidence of extrapyramidal symptoms was lower with bromperidol than haloperidol generally. Among the items of extrapyramidal symptoms, expressive autonomic movements bradykinesia, rigidity, gate and posture and akathisia were often with haloperidol, and the only one item, tremor, was more often with bromperidol.
These findings suggest that bromperidol is a safe and potent antipsychotic drug which can be used in the treatment of schizophrenia selectively.
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